Shorter dinucleotide repeat length in the DRD5 gene is associated with attention deficit hyperactivity disorder.
نویسندگان
چکیده
Department of Child and Adolescent Psychiatry, Seoul National University Hospital, Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Department of Psychiatry, Chonbuk National University School of Medicine, Jeonju, Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Department of Psychiatry, Kyungpook National University Hospital, Daegu, Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Korea and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA Correspondence to Tae Won Park, MD, PhD, Department of Psychiatry, Chonbuk National University School of Medicine, San 2-20, Geumam-dong, Deokjin-gu, Jeonju 561-756, Korea Tel: + 82 63 25
منابع مشابه
Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD.
There is considerable evidence to support a role of dopamine-related genes in the molecular aetiology of attention-deficit hyperactivity disorder (ADHD). A microsatellite located near the dopamine D5 receptor (DRD5) gene has been associated with ADHD in a number of studies, but other polymorphisms within the vicinity of this gene have not been examined. In this study we genotyped three microsat...
متن کاملJoint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant genetic component, and theories of etiology include abnormalities in the dopaminergic system, with DRD4, DAT1, SNAP25, and DRD5 being implicated as major susceptibility genes. ...
متن کاملQuantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B.
It has been widely postulated that the categorical diagnosis of attention deficit hyperactivity disorder (ADHD) should be seen as the extreme end of a set of traits quantitatively distributed in the general population. A consequence of this is that the genes associated with DSM-IV ADHD should also influence these underlying traits in non-affected individuals. The aim of this study was to examin...
متن کاملMeta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD).
Molecular genetic investigations of attention deficit hyperactivity disorder (ADHD) have found associations with a variable number of tandem repeat (VNTR) situated in the 3'-untranslated region of dopamine transporter gene (DAT1), a VNTR in exon 3 of dopamine receptor 4 gene (DRD4) and a microsatellite polymorphism located at 18.5 kb from the 5' end of dopamine receptor 5 gene (DRD5). A number ...
متن کاملStudy of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri
BackgroundAttention deficit hyperactivity disorder (ADHD), is a multifactorial disorder and converging evidence has implicated abnormalities of dopamine neurotransmission. The aim of this study was to examine the association of -141 polymorphisms in DRD2 gene with ADHA among Iranian-Azeri population.Materials and Methods A case–control association study included 153 patients with attention defi...
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عنوان ژورنال:
- Psychiatric genetics
دوره 19 1 شماره
صفحات -
تاریخ انتشار 2009